| Date | Opponent | Venue | Fixture | Score | Scorers | Attendance | Match Details |
|---|---|---|---|---|---|---|---|
| 21-Aug-65 | Huddersfield Town | Home | League | 0-2 | 7383 | ||
| 24-Aug-65 | Rotherham United | Away | League | 1-2 | Flatt | 7447 | |
| 28-Aug-65 | Crystal Palace | Away | League | 1-2 | Scott | 16543 | |
| 30-Aug-65 | Rotherham United | Home | League | 1-4 | Scott | 7172 | |
| 4-Sep-65 | Preston North End | Home | League | 2-2 | Flatt (2) | 6529 | |
| 8-Sep-65 | Birmingham City | Away | League | 2-2 | Scott (2) | 7958 | |
| 11-Sep-65 | Charlton Athletic | Away | League | 0-3 | 11406 | ||
| 13-Sep-65 | Birmingham City | Home | League | 2-1 | Flatt (2) | 7114 | |
| 18-Sep-65 | Plymouth Argyle | Home | League | 0-1 | 6753 | ||
| 22-Sep-65 | Coventry City | Home | LC r2 | 0-3 | 5326 | ||
| 25-Sep-65 | Portsmouth | Away | League | 1-4 | Flatt | 10613 | |
| 2-Oct-65 | Bolton Wanderers | Home | League | 1-0 | Smith | 7774 | |
| 9-Oct-65 | Wolverhampton Wanderers | Home | League | 0-3 | 11411 | ||
| 16-Oct-65 | Norwich City | Away | League | 1-2 | Sorrell | 13395 | |
| 23-Oct-65 | Bury | Home | League | 2-2 | Webb, Price | 6336 | |
| 30-Oct-65 | Southampton | Away | League | 0-1 | 15700 | ||
| 6-Nov-65 | Derby County | Home | League | 0-0 | 5980 | ||
| 13-Nov-65 | Cardiff City | Away | League | 1-3 | Allen | 9168 | |
| 20-Nov-65 | Carlisle United | Home | League | 2-1 | Flatt (2) | 3678 | |
| 27-Nov-65 | Coventry City | Away | League | 1-1 | Gregory | 20110 | |
| 4-Dec-65 | Bristol City | Home | League | 0-4 | 5559 | ||
| 11-Dec-65 | Manchester City | Away | League | 0-5 | 16202 | ||
| 27-Dec-65 | Middlesbrough | Away | League | 1-2 | Allen | 21107 | |
| 1-Jan-66 | Wolverhampton Wanderers | Away | League | 1-2 | Metchick | 20857 | |
| 8-Jan-66 | Cardiff City | Home | League | 1-1 | Nicholas | 5516 | |
| 15-Jan-66 | Bury | Away | League | 0-3 | 4293 | ||
| 22-Jan-66 | Norwich City | Home | FAC r3 | 1-3 | Price | 9494 | |
| 29-Jan-66 | Huddersfield Town | Away | League | 1-1 | Webb | 16011 | |
| 5-Feb-66 | Crystal Palace | Home | League | 0-2 | 7508 | ||
| 19-Feb-66 | Preston North End | Away | League | 2-1 | Webb, Metchick | 10640 | |
| 26-Feb-66 | Charlton Athletic | Home | League | 1-2 | Nicholas | 13451 | |
| 12-Mar-66 | Plymouth Argyle | Away | League | 1-1 | Gregory (pen) | 11280 | |
| 19-Mar-66 | Portsmouth | Home | League | 0-0 | 6429 | ||
| 26-Mar-66 | Bolton Wanderers | Away | League | 0-2 | 8557 | ||
| 28-Mar-66 | Norwich City | Home | League | 0-0 | 4740 | ||
| 2-Apr-66 | Derby County | Away | League | 3-1 | Metchick (2), Le Flem | 6810 | |
| 8-Apr-66 | Ipswich Town | Home | League | 1-4 | Le Flem | 7406 | |
| 11-Apr-66 | Ipswich Town | Away | League | 2-3 | Metchick (2) | 13342 | |
| 15-Apr-66 | Carlisle United | Away | League | 0-1 | 9811 | ||
| 18-Apr-66 | Middlesbrough | Home | League | 2-3 | Price (2) | 2286 | |
| 23-Apr-66 | Coventry City | Home | League | 1-1 | Metchick | 5800 | |
| 30-Apr-66 | Bristol City | Away | League | 0-2 | 11055 | ||
| 7-May-66 | Manchester City | Home | League | 2-2 | Metchick, Smith | 6109 | |
| 9-May-66 | Southampton | Home | League | 1-1 | Allen | 19839 |
