| Date | Opponent | Venue | Fixture | Score | Scorers | Attendance | Match Details |
|---|---|---|---|---|---|---|---|
| 18-Aug-62 | Arsenal | Home | League | 1-2 | Gibbs | 26300 | |
| 22-Aug-62 | West Bromwich Albion | Away | League | 1-2 | Dunmore | 22409 | |
| 25-Aug-62 | Birmingham City | Away | League | 2-2 | Graham, Dunmore (pen) | 23500 | |
| 29-Aug-62 | West Bromwich Albion | Home | League | 2-3 | Deeley, Dunmore | 17289 | |
| 1-Sep-62 | West Ham United | Home | League | 2-0 | Dunmore, Graham | 23912 | |
| 5-Sep-62 | Everton | Away | League | 0-3 | 51542 | ||
| 8-Sep-62 | Manchester United | Home | League | 1-0 | McDonald | 24901 | |
| 12-Sep-62 | Everton | Home | League | 3-0 | Deeley, Bolland, Dunmore | 21756 | |
| 15-Sep-62 | Burnley | Away | League | 0-2 | 24978 | ||
| 22-Sep-62 | Sheffield Wednesday | Home | League | 2-4 | Bolland, Deeley | 20125 | |
| 26-Sep-62 | Newcastle United | Away | LC r2 | 1-1 | Bolland | 22490 | |
| 29-Sep-62 | Fulham | Away | League | 2-0 | Graham, McDonald | 26505 | |
| 1-Oct-62 | Newcastle United | Home | LC r2r | 4-2 | Graham (2), Deeley, Bolland | 8037 | |
| 6-Oct-62 | Manchester City | Away | League | 0-2 | 19706 | ||
| 13-Oct-62 | Blackpool | Home | League | 0-2 | 17156 | ||
| 17-Oct-62 | Chester City | Home | LC r3 | 9-2 | Graham (3), Waites (3), Dunmore (2), Deeley | 7428 | |
| 20-Oct-62 | Aston Villa | Away | League | 0-1 | 29370 | ||
| 27-Oct-62 | Tottenham Hotspur | Home | League | 1-5 | Deeley | 30987 | |
| 3-Nov-62 | Nottingham Forest | Away | League | 1-1 | Dunmore | 17821 | |
| 10-Nov-62 | Ipswich Town | Home | League | 1-2 | Gregory | 13929 | |
| 12-Nov-62 | Charlton Athletic | Home | LC r4 | 3-2 | Foster (2), Gregory | 9602 | |
| 17-Nov-62 | Liverpool | Away | League | 0-5 | 30009 | ||
| 24-Nov-62 | Wolverhampton Wanderers | Home | League | 0-4 | 16431 | ||
| 1-Dec-62 | Blackburn Rovers | Away | League | 1-1 | Graham | 15500 | |
| 3-Dec-62 | Bury | Home | LC r5 | 0-2 | 6094 | ||
| 8-Dec-62 | Sheffield United | Home | League | 2-2 | Graham, Dunmore | 9874 | |
| 15-Dec-62 | Arsenal | Away | League | 0-2 | 29075 | ||
| 22-Dec-62 | Birmingham City | Home | League | 2-2 | Musgrove, Bolland | 11646 | |
| 26-Dec-62 | Leicester City | Away | League | 1-5 | Musgrove | 17303 | |
| 11-Feb-63 | Hull City | Home | FAC r3 | 1-1 | Musgrove | 9757 | |
| 16-Feb-63 | Fulham | Home | League | 1-1 | Graham | 17132 | |
| 19-Feb-63 | Hull City | Away | FAC r3r | 2-0 | Musgrove, Gibbs | 14214 | |
| 23-Feb-63 | Manchester City | Home | League | 1-1 | Elwood | 12464 | |
| 2-Mar-63 | Blackpool | Away | League | 2-3 | Dunmore, Deeley (pen) | 11732 | |
| 4-Mar-63 | Derby County | Home | FAC r4 | 3-0 | Dunmore, Elwood, Deeley | 12607 | |
| 9-Mar-63 | Aston Villa | Home | League | 0-2 | 11509 | ||
| 16-Mar-63 | Leicester City | Home | FAC r5 | 0-1 | 25769 | ||
| 23-Mar-63 | Nottingham Forest | Home | League | 0-1 | 14079 | ||
| 27-Mar-63 | Tottenham Hotspur | Away | League | 0-2 | 40260 | ||
| 30-Mar-63 | Wolverhampton Wanderers | Away | League | 1-2 | Graham | 13739 | |
| 3-Apr-63 | Leicester City | Home | League | 0-2 | 14780 | ||
| 12-Apr-63 | Bolton Wanderers | Home | League | 0-1 | 15369 | ||
| 13-Apr-63 | Ipswich Town | Away | League | 1-1 | Musgrove | 18678 | |
| 15-Apr-63 | Bolton Wanderers | Away | League | 1-0 | Dunmore | 16649 | |
| 20-Apr-63 | Blackburn Rovers | Home | League | 1-1 | Dunmore | 8274 | |
| 26-Apr-63 | Sheffield United | Away | League | 0-2 | 20703 | ||
| 2-May-63 | Liverpool | Home | League | 2-1 | Graham, Bishop | 8273 | |
| 4-May-63 | Sheffield Wednesday | Away | League | 1-3 | Graham | 20762 | |
| 7-May-63 | Burnley | Home | League | 0-1 | 10085 | ||
| 11-May-63 | West Ham United | Away | League | 0-2 | 16746 | ||
| 18-May-63 | Manchester United | Away | League | 1-3 | Dunmore | 32759 |
