| Date | Opponent | Venue | Fixture | Score | Scorers | Attendance |
|---|---|---|---|---|---|---|
| 18-Aug-62 | Arsenal | Home | League | 1-2 | Gibbs | 26,300 |
| 22-Aug-62 | West Bromwich Albion | Away | League | 1-2 | Dunmore | 22,409 |
| 25-Aug-62 | Birmingham City | Away | League | 2-2 | Graham, Dunmore (pen) | 23,500 |
| 29-Aug-62 | West Bromwich Albion | Home | League | 2-3 | Deeley, Dunmore | 17,289 |
| 01-Sep-62 | West Ham United | Home | League | 2-0 | Dunmore, Graham | 23,912 |
| 05-Sep-62 | Everton | Away | League | 0-3 | 51,542 | |
| 08-Sep-62 | Manchester United | Home | League | 1-0 | McDonald | 24,901 |
| 12-Sep-62 | Everton | Home | League | 3-0 | Deeley, Bolland, Dunmore | 21,756 |
| 15-Sep-62 | Burnley | Away | League | 0-2 | 24,978 | |
| 22-Sep-62 | Sheffield Wednesday | Home | League | 2-4 | Bolland, Deeley | 20,125 |
| 26-Sep-62 | Newcastle United | Away | LC r2 | 1-1 | Bolland | 22,490 |
| 29-Sep-62 | Fulham | Away | League | 2-0 | Graham, McDonald | 26,505 |
| 01-Oct-62 | Newcastle United | Home | LC r2r | 4-2 | Graham (2), Deeley, Bolland | 8,037 |
| 06-Oct-62 | Manchester City | Away | League | 0-2 | 19,706 | |
| 13-Oct-62 | Blackpool | Home | League | 0-2 | 17,156 | |
| 17-Oct-62 | Chester City | Home | LC r3 | 9-2 | Graham (3), Waites (3), Dunmore (2), Deeley | 7,428 |
| 20-Oct-62 | Aston Villa | Away | League | 0-1 | 29,370 | |
| 27-Oct-62 | Tottenham Hotspur | Home | League | 1-5 | Deeley | 30,987 |
| 03-Nov-62 | Nottingham Forest | Away | League | 1-1 | Dunmore | 17,821 |
| 10-Nov-62 | Ipswich Town | Home | League | 1-2 | Gregory | 13,929 |
| 12-Nov-62 | Charlton Athletic | Home | LC r4 | 3-2 | Foster (2), Gregory | 9,602 |
| 17-Nov-62 | Liverpool | Away | League | 0-5 | 30,009 | |
| 24-Nov-62 | Wolverhampton Wanderers | Home | League | 0-4 | 16,431 | |
| 01-Dec-62 | Blackburn Rovers | Away | League | 1-1 | Graham | 15,500 |
| 03-Dec-62 | Bury | Home | LC r5 | 0-2 | 6,094 | |
| 08-Dec-62 | Sheffield United | Home | League | 2-2 | Graham, Dunmore | 9,874 |
| 15-Dec-62 | Arsenal | Away | League | 0-2 | 29,075 | |
| 22-Dec-62 | Birmingham City | Home | League | 2-2 | Musgrove, Bolland | 11,646 |
| 26-Dec-62 | Leicester City | Away | League | 1-5 | Musgrove | 17,303 |
| 11-Feb-63 | Hull City | Home | FAC r3 | 1-1 | Musgrove | 9,757 |
| 16-Feb-63 | Fulham | Home | League | 1-1 | Graham | 17,132 |
| 19-Feb-63 | Hull City | Away | FAC r3r | 2-0 | Musgrove, Gibbs | 14,214 |
| 23-Feb-63 | Manchester City | Home | League | 1-1 | Elwood | 12,464 |
| 02-Mar-63 | Blackpool | Away | League | 2-3 | Dunmore, Deeley (pen) | 11,732 |
| 04-Mar-63 | Derby County | Home | FAC r4 | 3-0 | Dunmore, Elwood, Deeley | 12,607 |
| 09-Mar-63 | Aston Villa | Home | League | 0-2 | 11,509 | |
| 16-Mar-63 | Leicester City | Home | FAC r5 | 0-1 | 25,769 | |
| 23-Mar-63 | Nottingham Forest | Home | League | 0-1 | 14,079 | |
| 27-Mar-63 | Tottenham Hotspur | Away | League | 0-2 | 40,260 | |
| 30-Mar-63 | Wolverhampton Wanderers | Away | League | 1-2 | Graham | 13,739 |
| 03-Apr-63 | Leicester City | Home | League | 0-2 | 14,780 | |
| 12-Apr-63 | Bolton Wanderers | Home | League | 0-1 | 15,369 | |
| 13-Apr-63 | Ipswich Town | Away | League | 1-1 | Musgrove | 18,678 |
| 15-Apr-63 | Bolton Wanderers | Away | League | 1-0 | Dunmore | 16,649 |
| 20-Apr-63 | Blackburn Rovers | Home | League | 1-1 | Dunmore | 8,274 |
| 26-Apr-63 | Sheffield United | Away | League | 0-2 | 20,703 | |
| 02-May-63 | Liverpool | Home | League | 2-1 | Graham, Bishop | 8,273 |
| 04-May-63 | Sheffield Wednesday | Away | League | 1-3 | Graham | 20,762 |
| 07-May-63 | Burnley | Home | League | 0-1 | 10,085 | |
| 11-May-63 | West Ham United | Away | League | 0-2 | 16,746 | |
| 18-May-63 | Manchester United | Away | League | 1-3 | Dunmore | 32,759 |