| Date | Opponent | Venue | Fixture | Score | Scorers | Attendance | Match Details |
|---|---|---|---|---|---|---|---|
| 27-Aug-27 | Grimsby Town | Away | League | 2-2 | Kerr, Dennison | 15051 | |
| 29-Aug-27 | Southampton | Home | League | 2-0 | Dennison, Corkindale | 13711 | |
| 3-Sep-27 | Reading | Home | League | 3-0 | Duffy, Whipp, Kerr | 18593 | |
| 5-Sep-27 | Southampton | Away | League | 3-1 | Dennison (2), Whipp | 7982 | |
| 10-Sep-27 | Blackpool | Away | League | 1-0 | Kerr | 12337 | |
| 17-Sep-27 | Chelsea | Home | League | 2-1 | Whipp, Kerr | 34838 | |
| 24-Sep-27 | Barnsley | Away | League | 2-4 | Gardner (2) | 11951 | |
| 1-Oct-27 | West Bromwich Albion | Away | League | 1-4 | Corkindale | 19994 | |
| 8-Oct-27 | Bristol City | Home | League | 4-2 | Dennison (3), Whipp | 21202 | |
| 15-Oct-27 | Stoke City | Away | League | 0-2 | 15009 | ||
| 22-Oct-27 | Preston North End | Home | League | 1-1 | Dennison | 10533 | |
| 29-Oct-27 | Swansea Town | Away | League | 0-5 | 12562 | ||
| 5-Nov-27 | Fulham | Home | League | 3-2 | Gardner (2), Dennison | 15877 | |
| 12-Nov-27 | Hull City | Away | League | 2-2 | Gardner, Smith | 6682 | |
| 19-Nov-27 | Manchester City | Home | League | 0-2 | 14129 | ||
| 26-Nov-27 | South Shields AFC | Away | League | 2-2 | Whipp (2) | 5771 | |
| 3-Dec-27 | Leeds United | Home | League | 2-1 | Kerr (2) | 12838 | |
| 10-Dec-27 | Nottingham Forest | Away | League | 3-4 | Collins, Whipp (2) | 7802 | |
| 17-Dec-27 | Port Vale | Home | League | 0-1 | 9827 | ||
| 24-Dec-27 | Wolverhampton Wanderers | Away | League | 3-5 | Whipp, Holland, McDougall (og) | 6023 | |
| 27-Dec-27 | Oldham Athletic | Away | League | 0-5 | 23333 | ||
| 31-Dec-27 | Grimsby Town | Home | League | 1-2 | Holland | 8738 | |
| 7-Jan-28 | Reading | Away | League | 0-4 | 10533 | ||
| 14-Jan-28 | Swindon Town | Away | FAC r3 | 1-2 | Whipp | 19079 | |
| 21-Jan-28 | Blackpool | Home | League | 2-5 | Gardner (2, 1 pen) | 11401 | |
| 28-Jan-28 | Chelsea | Away | League | 0-1 | 17875 | ||
| 4-Feb-28 | Barnsley | Home | League | 2-0 | Broadbent, Whipp | 8985 | |
| 11-Feb-28 | West Bromwich Albion | Home | League | 0-0 | 11443 | ||
| 18-Feb-28 | Bristol City | Away | League | 1-5 | Streets | 15432 | |
| 25-Feb-28 | Stoke City | Home | League | 3-2 | Turnbull, Whipp, Williams | 20084 | |
| 3-Mar-28 | Preston North End | Away | League | 0-0 | 18886 | ||
| 10-Mar-28 | Swansea Town | Home | League | 1-1 | Turnbull | 11508 | |
| 17-Mar-28 | Fulham | Away | League | 0-2 | 21452 | ||
| 24-Mar-28 | Hull City | Home | League | 0-0 | 8869 | ||
| 31-Mar-28 | Manchester City | Away | League | 3-5 | Turnbull (2), Batten | 38272 | |
| 6-Apr-28 | Notts County | Away | League | 0-3 | 13924 | ||
| 7-Apr-28 | South Shields AFC | Home | League | 2-2 | Dennison, Turnbull | 11019 | |
| 9-Apr-28 | Notts County | Home | League | 0-1 | 10166 | ||
| 14-Apr-28 | Leeds United | Away | League | 0-4 | 22884 | ||
| 16-Apr-28 | Oldham Athletic | Home | League | 2-0 | Corkindale, Kerr | 2929 | |
| 21-Apr-28 | Nottingham Forest | Home | League | 2-2 | Whipp, Kerr | 9451 | |
| 28-Apr-28 | Port Vale | Away | League | 0-0 | 5966 | ||
| 5-May-28 | Wolverhampton Wanderers | Home | League | 0-0 | 12891 |
