| Date | Opponent | Venue | Fixture | Score | Scorers | Attendance | Match Details |
|---|---|---|---|---|---|---|---|
| 19-Aug-50 | Plymouth Argyle | Away | League | 1-2 | Blair | 21633 | |
| 23-Aug-50 | Ipswich Town | Away | League | 2-2 | Blair, Pattison | 12444 | |
| 26-Aug-50 | Reading | Home | League | 2-0 | Pattison, Simmonds | 21298 | |
| 31-Aug-50 | Ipswich Town | Home | League | 2-0 | Blair (2) | 15408 | |
| 2-Sep-50 | Southend United | Away | League | 1-0 | Pattison | 14698 | |
| 7-Sep-50 | Northampton Town | Home | League | 1-0 | Blair | 17867 | |
| 9-Sep-50 | Exeter City | Home | League | 1-3 | Pattison | 17187 | |
| 14-Sep-50 | Northampton Town | Away | League | 3-3 | Sutherland (2), Pattison | 11344 | |
| 16-Sep-50 | Bournemouth & Boscombe Athletic | Away | League | 0-5 | 15775 | ||
| 18-Sep-50 | Millwall | Away | League | 1-3 | Sutherland | 22651 | |
| 23-Sep-50 | Gillingham | Home | League | 4-0 | Rees (2), Davies, Blair | 16005 | |
| 30-Sep-50 | Bristol City | Away | League | 1-4 | Blair | 16286 | |
| 7-Oct-50 | Port Vale | Away | League | 1-3 | Rees | 12899 | |
| 14-Oct-50 | Nottingham Forest | Home | League | 0-4 | 15348 | ||
| 21-Oct-50 | Torquay United | Away | League | 1-2 | Sherratt | 7055 | |
| 28-Oct-50 | Aldershot | Home | League | 1-0 | Blair | 10115 | |
| 4-Nov-50 | Swindon Town | Away | League | 0-2 | 9277 | ||
| 18-Nov-50 | Bristol Rovers | Away | League | 1-2 | Blair | 14462 | |
| 25-Nov-50 | Ipswich Town | Home | FAC r1 | 1-2 | Rees | 10560 | |
| 2-Dec-50 | Brighton & Hove Albion | Away | League | 0-3 | 9695 | ||
| 9-Dec-50 | Colchester United | Home | League | 1-1 | Sutherland | 8716 | |
| 23-Dec-50 | Reading | Away | League | 0-4 | 10882 | ||
| 25-Dec-50 | Watford | Away | League | 0-2 | 7983 | ||
| 26-Dec-50 | Watford | Home | League | 1-2 | Sherratt (pen) | 9827 | |
| 30-Dec-50 | Southend United | Home | League | 1-1 | McGeachy | 7793 | |
| 11-Jan-51 | Norwich City | Home | League | 3-1 | Blair (2), Sutherland | 4475 | |
| 13-Jan-51 | Exeter City | Away | League | 0-0 | 9392 | ||
| 20-Jan-51 | Bournemouth & Boscombe Athletic | Home | League | 2-0 | Sutherland, Jackson | 9813 | |
| 1-Feb-51 | Norwich City | Away | League | 1-3 | Rees | 12500 | |
| 3-Feb-51 | Gillingham | Away | League | 0-1 | 8352 | ||
| 10-Feb-51 | Crystal Palace | Home | League | 2-0 | Jackson, Walton | 11763 | |
| 24-Feb-51 | Port Vale | Home | League | 2-3 | Sherratt, Blizzard | 6861 | |
| 3-Mar-51 | Nottingham Forest | Away | League | 1-0 | Sherratt | 22504 | |
| 10-Mar-51 | Torquay United | Home | League | 5-1 | Blair (3), Rees (2) | 6558 | |
| 17-Mar-51 | Aldershot | Away | League | 1-3 | Rees | 7414 | |
| 23-Mar-51 | Walsall | Home | League | 2-1 | Deverall, Blair | 9827 | |
| 24-Mar-51 | Swindon Town | Home | League | 2-1 | Blair, Pattison | 10029 | |
| 26-Mar-51 | Walsall | Away | League | 1-1 | Walton | 8437 | |
| 31-Mar-51 | Colchester United | Away | League | 0-1 | 9291 | ||
| 7-Apr-51 | Bristol Rovers | Home | League | 1-0 | Walton | 6245 | |
| 12-Apr-51 | Newport County | Home | League | 0-3 | 8270 | ||
| 14-Apr-51 | Crystal Palace | Away | League | 1-1 | Rees | 10390 | |
| 19-Apr-51 | Millwall | Home | League | 0-2 | 16607 | ||
| 21-Apr-51 | Brighton & Hove Albion | Home | League | 2-1 | Rees, Walton | 9405 | |
| 26-Apr-51 | Plymouth Argyle | Home | League | 1-2 | Rees | 8002 | |
| 28-Apr-51 | Newport County | Away | League | 0-0 | 7564 | ||
| 3-May-51 | Bristol City | Home | League | 0-2 | 6479 |
