| 24-Aug-57 | Grimsby Town | Away | League | 2-7 | Johnston (2) | 14274 | |
| 28-Aug-57 | Doncaster Rovers | Away | League | 0-2 | | 12000 | |
| 31-Aug-57 | Stoke City | Home | League | 0-2 | | 17497 | |
| 5-Sep-57 | Doncaster Rovers | Home | League | 2-0 | Johnston (2) | 16000 | |
| 7-Sep-57 | Bristol City | Away | League | 2-2 | Heckman, Johnston | 23043 | |
| 12-Sep-57 | Charlton Athletic | Away | League | 2-3 | Johnston (2) | 17856 | |
| 14-Sep-57 | Cardiff City | Home | League | 4-2 | Johnston (2, 1 pen), Julians, Milne (og) | 16852 | |
| 19-Sep-57 | Charlton Athletic | Home | League | 3-2 | Johnston (2), Heckman | 18552 | |
| 21-Sep-57 | Liverpool | Away | League | 0-3 | | 36077 | |
| 28-Sep-57 | Middlesbrough | Home | League | 4-0 | Julians (4) | 18487 | |
| 5-Oct-57 | West Ham United | Away | League | 2-3 | Johnston, Heckman | 26000 | |
| 12-Oct-57 | Barnsley | Home | League | 2-1 | Johnston (2, 1 pen) | 15149 | |
| 19-Oct-57 | Fulham | Away | League | 1-3 | Julians | 30000 | |
| 26-Oct-57 | Swansea Town | Home | League | 5-1 | Johnston (3), Heckman, White | 16354 | |
| 2-Nov-57 | Derby County | Away | League | 0-2 | | 20195 | |
| 9-Nov-57 | Bristol Rovers | Home | League | 1-3 | Carey | 14834 | |
| 16-Nov-57 | Lincoln City | Away | League | 0-2 | | 6139 | |
| 23-Nov-57 | Notts County | Home | League | 2-2 | Johnston (2) | 12361 | |
| 30-Nov-57 | Ipswich Town | Away | League | 3-5 | Hartburn, Julians, Johnston | 17412 | |
| 7-Dec-57 | Blackburn Rovers | Home | League | 5-1 | Johnston (2), Julians (2), White | 11038 | |
| 14-Dec-57 | Sheffield United | Away | League | 2-0 | Julians, Johnston | 14715 | |
| 21-Dec-57 | Grimsby Town | Home | League | 5-1 | Johnston (3), Julians, Hartburn | 13106 | |
| 25-Dec-57 | Rotherham United | Home | League | 6-2 | Woosnam, Johnston (4), Hartburn | 13956 | |
| 26-Dec-57 | Rotherham United | Away | League | 2-2 | White, Johnston | 10935 | |
| 28-Dec-57 | Stoke City | Away | League | 3-1 | Johnston, Julians, Woosnam | 27568 | |
| 4-Jan-58 | Reading | Home | FAC r3 | 1-0 | Johnston | 20781 | |
| 11-Jan-58 | Bristol City | Home | League | 4-0 | Johnston (3), Woosnam | 15862 | |
| 18-Jan-58 | Cardiff City | Away | League | 1-1 | Julians | 14000 | |
| 25-Jan-58 | Cardiff City | Away | FAC r4 | 1-4 | Julians | 35000 | |
| 1-Feb-58 | Liverpool | Home | League | 1-0 | Hartburn (pen) | 18568 | |
| 20-Feb-58 | West Ham United | Home | League | 1-4 | Julians | 25284 | |
| 22-Feb-58 | Notts County | Away | League | 1-0 | Pritchard (og) | 11494 | |
| 8-Mar-58 | Swansea Town | Away | League | 2-1 | White, Hartburn | 15000 | |
| 13-Mar-58 | Fulham | Home | League | 1-3 | Facey | 12407 | |
| 15-Mar-58 | Derby County | Home | League | 1-1 | Julians | 13299 | |
| 19-Mar-58 | Middlesbrough | Away | League | 0-2 | | 22000 | |
| 22-Mar-58 | Bristol Rovers | Away | League | 0-4 | | 15533 | |
| 29-Mar-58 | Lincoln City | Home | League | 1-0 | McMahon | 9637 | |
| 4-Apr-58 | Huddersfield Town | Home | League | 3-1 | Willemse, White, Andrews | 16840 | |
| 5-Apr-58 | Barnsley | Away | League | 0-3 | | 8732 | |
| 8-Apr-58 | Huddersfield Town | Away | League | 0-2 | | 14886 | |
| 12-Apr-58 | Ipswich Town | Home | League | 2-0 | Julians, Facey | 10122 | |
| 19-Apr-58 | Blackburn Rovers | Away | League | 1-4 | Carey | 24900 | |
| 26-Apr-58 | Sheffield United | Home | League | 0-1 | | 8833 | |