| 20-Aug-60 | Ipswich Town | Home | League | 1-3 | Johnston | 14789 | |
| 24-Aug-60 | Brighton & Hove Albion | Away | League | 1-1 | Johnston | 17797 | |
| 27-Aug-60 | Scunthorpe United | Away | League | 2-2 | Johnston (2) | 10107 | |
| 31-Aug-60 | Brighton & Hove Albion | Home | League | 2-1 | Bishop, Facey (pen) | 12937 | |
| 3-Sep-60 | Sheffield United | Home | League | 1-4 | Brown | 10914 | |
| 7-Sep-60 | Leeds United | Away | League | 3-1 | Waites, Johnston, Graham | 17363 | |
| 10-Sep-60 | Derby County | Home | League | 2-1 | Johnston (2) | 10230 | |
| 14-Sep-60 | Leeds United | Home | League | 0-1 | | 8505 | |
| 17-Sep-60 | Bristol Rovers | Away | League | 2-4 | Elwood, Graham | 15337 | |
| 24-Sep-60 | Liverpool | Home | League | 1-3 | Graham | 10921 | |
| 1-Oct-60 | Rotherham United | Away | League | 1-2 | Facey | 7338 | |
| 8-Oct-60 | Stoke City | Away | League | 2-1 | Brown, Johnston | 8349 | |
| 12-Oct-60 | Chester | Away | LC r1 | 2-2 | Foster, Brown | 9074 | |
| 15-Oct-60 | Swansea Town | Home | League | 2-2 | Johnston, Brown | 10989 | |
| 17-Oct-60 | Chester | Home | LC r1r | 1-0 | McDonald | 5002 | |
| 22-Oct-60 | Luton Town | Away | League | 1-0 | Brown | 10989 | |
| 29-Oct-60 | Lincoln City | Home | League | 1-2 | Brown | 5793 | |
| 5-Nov-60 | Portsmouth | Away | League | 2-1 | White, Johnston | 11050 | |
| 14-Nov-60 | Chesterfield | Home | LC r2 | 0-1 | | 5243 | |
| 19-Nov-60 | Sunderland | Away | League | 1-4 | Brown | 16815 | |
| 3-Dec-60 | Norwich City | Away | League | 2-3 | Johnston, Waites | 19463 | |
| 10-Dec-60 | Charlton Athletic | Home | League | 1-1 | Gibbs | 9141 | |
| 17-Dec-60 | Ipswich Town | Away | League | 2-6 | Johnston, McDonald | 9772 | |
| 26-Dec-60 | Middlesbrough | Away | League | 0-2 | | 15996 | |
| 31-Dec-60 | Scunthorpe United | Home | League | 2-1 | Foster, Johnston | 8430 | |
| 7-Jan-61 | Gillingham | Away | FAC r3 | 6-2 | Elwood (2), Lewis (2, 2 pens), Johnston, McDonald | 13161 | |
| 14-Jan-61 | Sheffield United | Away | League | 1-4 | Elwood | 17438 | |
| 21-Jan-61 | Derby County | Away | League | 1-3 | Crossan | 11532 | |
| 28-Jan-61 | Southampton | Away | FAC r4 | 1-0 | Gibbs | 21392 | |
| 4-Feb-61 | Bristol Rovers | Home | League | 3-2 | Bishop, Newman, Lewis (pen) | 12334 | |
| 11-Feb-61 | Liverpool | Away | League | 0-5 | | 22131 | |
| 18-Feb-61 | Sheffield Wednesday | Home | FAC r5 | 0-2 | | 31000 | |
| 20-Feb-61 | Rotherham United | Home | League | 2-1 | Lambert (og), Lewis (pen) | 9613 | |
| 4-Mar-61 | Swansea Town | Away | League | 0-1 | | 14000 | |
| 7-Mar-61 | Plymouth Argyle | Home | League | 1-1 | Crossan | 9637 | |
| 11-Mar-61 | Luton Town | Home | League | 2-1 | Bishop, Sealey | 11918 | |
| 14-Mar-61 | Middlesbrough | Home | League | 1-1 | McDonald | 11658 | |
| 18-Mar-61 | Charlton Athletic | Away | League | 0-2 | | 12353 | |
| 21-Mar-61 | Huddersfield Town | Home | League | 2-0 | Graham, Dunmore | 10099 | |
| 25-Mar-61 | Portsmouth | Home | League | 2-1 | Graham, Johnston | 10181 | |
| 29-Mar-61 | Southampton | Home | League | 1-1 | McDonald | 11247 | |
| 1-Apr-61 | Plymouth Argyle | Away | League | 2-3 | Dunmore, Facey (pen) | 14814 | |
| 3-Apr-61 | Southampton | Away | League | 1-1 | Dunmore | 12199 | |
| 8-Apr-61 | Sunderland | Home | League | 0-1 | | 12765 | |
| 10-Apr-61 | Stoke City | Home | League | 3-1 | Graham (2), Johnston | 8349 | |
| 15-Apr-61 | Huddersfield Town | Away | League | 0-1 | | 12247 | |
| 22-Apr-61 | Norwich City | Home | League | 1-0 | Johnston | 12106 | |
| 29-Apr-61 | Lincoln City | Away | League | 0-2 | | 3996 | |
